Re: A couple of questions

From: zygote@ICSI.Net
Mon Mar 9 11:13:10 1998


> Date: Sun, 8 Mar 1998 22:46:24 -0600
> Reply-to: ob-gyn-l@obgyn.net
> From: mark decker <mdecker@nconnect.net>
> To: Multiple recipients of list <ob-gyn-l@talk.obgyn.net>
> Subject: Re: A couple of questions

>> they converted over some time back to using steroids after 32
weeks to 35 > if the other criteria of no infection are present. can't tell you when
> they made the switch but I think it was over a year ago. some newer data
> and or newer common opinion asa i remember led to this change in
> philosophy. somebody help me out here.

The issue of appropriate window beyond 34 weeks is not answered nor is it likely to be answered. The reason is that the studies to date asking the question of whether steroids help have used relatively small populations since the incidence of RDS is high in the preterm and VLBW fetuses. Given surfactant availability now and the 1000's of patients required to answer the question in a controlled prospective fashion, I do not believe it will be done.

That raises the second issue as to when should you stop giving steroids. My answer is a simple one. If you beliweve either because of gestation age 34-36 weeks or even later with known immature pulm status per amnio, then can with rationale thought give steroids. The down side riskd are truly minimal. I am sure that there are some antisteroid gurus out there and I am sure they will reply to your post. Robert J. Carpenter, Jr. MD St. Luke's Medical Tower,#2720 6624 Fannin,Houston,Tx 77030 zygote@icsi.net 713-795-4600 FAX:713-795-4422





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