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Re: Abnormal triple screenFrom: AFPPLUS3 (AFPPLUS3@aol.com)Thu Feb 26 21:20:23 1998
In a message dated 98-02-26 19:55:02 EST, you write:
<< "quad screen" adds alpha-HCG to the usual other 3 - it adds a little to the
sensitivity of the test - because both are used it is better to refer to the
test as maternal serum screening (MSS) for aneupoidy/ NTD rather than the
triple test.
>> Peter Wein Senior Lecturer Department of Obstetrics and Gynaecology University of Melbourne, Mercy Hospital for Women Clarendon Street, East Melbourne 3002 Australia Tel: +61 3 9270 2556 Fax: +61 3 9417 5406 Mobile: 0414 691690 Your comments were correct up to 1996 in the UK , and 1998 in the USA, however what I mean by the term Quad test or as it is also know as MMS is the addition of inhibin A to the other (two) or three most used markers. With the addition of inhibin A a 7-10% increased detection of Down syndrome is realized, with a small decrease in the screen positive rate. I know two labs in the UK using this test, Professor N. Wald in London, and Professor H. Cuckle in Leeds. In the USA there are only two Labs that I know of who are offering the "AFPPLUS "Quad test" clinically, our lab at Montefiore Medical Center in the Bronx, New York, and Jack Canick's lab at Womens and Infants Hospital, PR. While the assay for inhibin A is available X-USA, and I must add there has only been one shown to be affective in screening for Down syndrome, in the USA there are none FDA and therefore home brew assays must be used. Leonard H. Kellner Adm. Director Reproductive Genetics Lab Montefiore Medical Center, Dept. Ob/Gyn Associate Albert Einstein College of Medicine
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