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Re: "98d DMPA cycle" source needed; N so far From: Tessler (tessler@frontiernet.net) Thu Feb 19 08:19:06 1998 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: FlynnCNM@aol.com: "Re: Dr. Sanchez-Ramos & CNM's" Previous message: Luis Sanchez-Ramos: "Re: Dr. Sanchez-Ramos & CNM's" In reply to: Geffrey H. Klein, MD: "FLAME: female circumcision" Next in thread: Ari Gold: "Re: Dr. Sanchez-Ramos & CNM's" What I wrote matches the notes I made and my recollection. Unfortunately, I did not copy the article and can't swear that it wasn't a typo. However, I suspect the discrepancy between our concept of physiology and the labels used in the study can be explained by the use of estradiol and progesterone measurements as proxies for luteal and follicular function. In support of this explanation, I have an article on DMPA pharmacokinetics that says of Fotherby's study, "In this study the MPA levels fell more rapidly than in the other two studies, and the progesterone levels initially rose about 3.5 months after an injection of 150 mg of DMPA -- much earlier than reported in the other two studies." (Mishell, D.R. Jr. (1996). Pharmacokinetics of depot medroxyprogesterone acetate contraception. Journal of Reproductive Medicine, 41 (5 supp), 381-390.) Regards, Patti Tessler, RN, Family Nurse Practitioner Orange County, New York, USA tessler@frontiernet.net At 11:03 AM 2/18/98 -0600, "R. Daniel Braun, M.D." <rbraun@iunet.iupui.edu> wrote: >I find it interesting that Fotherby found reumption of "Luteal" function as >early as 66 days, but no evidence of "Follicular" function before 104 days. >I thought a follicle was necessary to lead to Luteal function. Or is this a >typo? -----Original Message----- >Fortherby et al. measured plasma estradiol and progesterone as indicators >of resumption of follicular and luteal activity. Only five (5) women were >tested after a 150 mg DMPA dose. The ranges in these women were 66 to over >167 days for resumption of luteal function, and 104 to over 167 days for >resumption of follicular function. The authors noted that these results >were preliminary, and referred to a 90 day cycle for reinjection as the >standard. Next message: FlynnCNM@aol.com: "Re: Dr. Sanchez-Ramos & CNM's" Previous message: Luis Sanchez-Ramos: "Re: Dr. Sanchez-Ramos & CNM's" In reply to: Geffrey H. Klein, MD: "FLAME: female circumcision" Next in thread: Ari Gold: "Re: Dr. Sanchez-Ramos & CNM's"

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