Re: Adverse effects of terbutaline: response to Dr. Joe

From: Dr Eberhard W Lisse (el@linux.lisse.na)
Wed Dec 31 05:27:52 1997


In message <3adda087.34a9dcef@aol.com>, DoctorJoe writes:

> Orally administered terbutaline is absorbed 30-70% (decreased by food) and you
> get about a 1mcg/L serum concentration per 1 mg administered. Subcutaneous
> injection, however, is obviously totally absorbed, and 0.5mg given subQ gives
> a plasma level of about 7.6 mcg/L. So whether you talk about letters to the
> editor or not, 20 mg of subQ terbutaline will more likely kill you than 20 mg
> po. I don't see that that's any science that a freshman or sophomore medical
> student can't handle...

I always wondered why Propanolol is given 40mg per os and 1mg ivi. I then RTFM (or rather RTFPI) telling me about bioavailability in relation to route of administration :-)-O

While we are at it, what are the side effects or risks with Nifedipine as tocolytic?

el





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