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Re: Adverse effects of terbutaline: response to Dr. JoeFrom: DoctorJoe (DoctorJoe@aol.com)Tue Dec 30 22:50:26 1997
In a message dated 12/30/97 6:13:30 PM, you wrote: <<Where are the data that show that 20 mg of terbutaline qiven SQ via infusion pump is FAR, FAR higher than giving it by the oral route. Show me the data! The dose used was perhaps higher than usual, but that "usual" dose was not obtained through well designed pharmacokinetic studies. A "Letter to the Editor" is hardly scientific evidence.>> Sorry to say, but science is science. Orally administered terbutaline is absorbed 30-70% (decreased by food) and you get about a 1mcg/L serum concentration per 1 mg administered. Subcutaneous injection, however, is obviously totally absorbed, and 0.5mg given subQ gives a plasma level of about 7.6 mcg/L. So whether you talk about letters to the editor or not, 20 mg of subQ terbutaline will more likely kill you than 20 mg po. I don't see that that's any science that a freshman or sophomore medical student can't handle... Joe P.
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