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Re: Adverse effects of terbutaline: response to Dr. JoeFrom: Luis Sanchez-Ramos (sanchez-ramos@worldnet.att.net)Tue Dec 30 17:08:47 1997
At Tue, 30 Dec 1997, DoctorJoe wrote: > >In a message dated 12/29/97 5:54:53 PM, you wrote: > ><<The mother whose neonate had myocardial necrosis was not OVERDOSED. The >dose used was in excess of those dosages commonly used with subcutaneous >terbutaline pump therapy. The daily dose was less than 20 mg/day of >terbutaline (similar to oral therapy). >> > >Sorry, but that's the problem. Giving someone 20 mg per day SUBCUTANEOUSLY is >FAR FAR higher than giving it orally, which is absorbed at a much smaller >amount. This lady WAS overdosed. And it's single cases like this that are >blown out of proportion, etc, etc, etc. > >So let's say this, Drug X, when given incorrectly, may cause massive problems >in some patients. When given correctly, it has known side effects which the >astute physician will be careful of and watch for. > >Fill in the X.... terb, Mg++, aspirin, whatEVER. > >Joe P. Where are the data that show that 20 mg of terbutaline qiven SQ via infusion pump is FAR, FAR higher than giving it by the oral route. Show me the data! The dose used was perhaps higher than usual, but that "usual" dose was not obtained through well designed pharmacokinetic studies. A "Letter to the Editor" is hardly scientific evidence. LSR
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