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Re: Prematurity vs Chemotherapy From: Dr. A. Hensenne (cdtg@skynet.be) Tue Dec 30 16:59:40 1997 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Luis Sanchez-Ramos: "Re: FDA letter in regard to terbutaline as a tocolytic" Previous message: Luis Sanchez-Ramos: "Response to Joe P" Maybe in reply to: Yoram Friedman: "Prematurity vs Chemotherapy" Next in thread: Bernard Cristalli: "Re: Prematurity vs Chemotherapy" Cytoxan=cyclophosphamide= alkylating agent. Oncovin= vinka alkaloïd-blok cells in mitosis->tubulin. Adryamycin= anthracycline, intercalate with DNA & RNA synthesis ...mutagenic & carcinogenic... All this drugs are toxic, but together = big bomb for the mother & super bomb for the fetus. The fetus should be delivered before chemotherapy, but mature lungs by steroids before. Bien amicalement. Dr Alain Hensenne cdtg@skynet.be 72 rue verte 4100 Seraing (LIEGE) - Belgium - Gynécologie médicale et chirurgicale -----Message d'origine----- De : Yoram Friedman <yorff@ibm.net> À : Multiple recipients of list <ob-gyn-l@talk.obgyn.net> Date : mardi 30 décembre 1997 15:37 Objet : Prematurity vs Chemotherapy >Here is a Dillema we face: > >Patient is pregnant 28.5 weeks gestation. >B-CELL Lymphoma, occupying most of the left lung and mediastinum. >On MRI there is no involvement of the spleen, liver or >retroperitoneal lymph-nodes. >Patient is considered for Cytoxan, Oncovin, Adriamycin and Prednison >treatmen. > >Should the fetus be delivered before chemotherapy ? > >The dilemma: complications of prematurity versus unknown >long term sequelae of chemotherapy exposure in utero. > >Can anyone help ? > Next message: Luis Sanchez-Ramos: "Re: FDA letter in regard to terbutaline as a tocolytic" Previous message: Luis Sanchez-Ramos: "Response to Joe P" Maybe in reply to: Yoram Friedman: "Prematurity vs Chemotherapy" Next in thread: Bernard Cristalli: "Re: Prematurity vs Chemotherapy"

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