Re: Hereditary angioneurotic edema and pregnancy

From: Malcolm Griffiths (Malcolm@mgriff22.demon.co.uk)
Tue Dec 9 15:08:08 1997


In message <199712091943.NAA18021@talk.obgyn.net>, Bostjan Lovsin <bostjan.lovsin@guest.arnes.si> writes >I have a problem: a 14-weeks-pregnant woman with hereditary
>angioneurotic edema and two attacks of severe abdominal pain already in
>this (first) pregnancy. We managed them with fresh frozen plasma, quite
>successfully. I have found some good articles through Medline, but
>still have some questions:
>1. Any experience with this?

Peripherally involved with two cases. Both have been published one by Boulos and Williams, one by Schild and Owens. >2. Where to get C1 inactivator for therapy and prophylaxys?

We didn't have a problem. >3. Your experience with allergic reaction to plasma?

Can't say. >4. Where to get tranexamic acid for therapy and prophylaxys?
Tranexemic acid is widely available on prescription in most of Europe. It is widely used for dysfunctional uterine bleeding.

What about Danazol as prophylaxis - partic in 3rd trimester?

--
Malcolm Griffiths               MD,MRCOG,MFFP,Cert.Mgmnt
Obstetrician & Gynaecologist    Luton & Dunstable Hosp.,UK.
Tel:    01582-497459 (office)   Fax:    01582-497376
        01525-222849 (home)     email:  Malcolm@mgriff22.demon.co.uk
http://www.obgyn.net/board/griffith.htm
"CLINICAL FREEDOM IS THE LAST REFUGE OF THE CLINICALLY INCOMPETENT!"
(Someone [1997])




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