Re: pharmacologic tocolysis

From: Malcolm Griffiths (Malcolm@mgriff22.demon.co.uk)
Sat Nov 29 11:03:12 1997


In message <v0310280fb0a2457d9046@[155.100.126.232]>, "Joseph B. Stanford" <stanford@MSSCC.MED.UTAH.EDU> writes >
>To my knowledge, no good RCT has ever examined this question:
>can THREATENED preterm labor (TPTL) (regular contractions WITHOUT cervical
>change) be effectively prevented from turning into ACTUAL preterm labor by
>the use of any number of tocolytics. (Understanding of course that some
>TPTL would never turn into PTL even spontaneously.)
>This would require a RCT in which women who had preterm ctx WITHOUT
>cervical change (TPTL) were randomized to a tocolytic or not and then rates
>of "conversion" to actual PTL (cervical change) and subsequent preterm
>delivery were the outcomes.
>to my knowledge, such a study has not been done. someone please correct me
>if I'm wrong.

I *THINK* you're wrong. I looked up the register of trial on the Cochrane database (the list of trials not meta-analyses) and those with abstracts list subjects either as women in preterm labour showing cervical changes or as merely in preterm labour (unspecified). Clearly one would need to read all of the papers to be certain. My uderstanding had long been that preterm labourers without changes had been included in many studies. Anyone lese *KNOW*? Malcolm Griffiths MD,MRCOG,MFFP,Cert.Mgmnt Obstetrician & Gynaecologist Luton & Dunstable Hosp.,UK. Tel: 01582-497459 (office) Fax: 01582-497376 01525-222849 (home) email: Malcolm@mgriff22.demon.co.uk http://www.obgyn.net/board/griffith.htm "CLINICAL FREEDOM IS THE LAST REFUGE OF THE CLINICALLY INCOMPETENT!" (Someone [1997])





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