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Re: Age of Menarche By the Kilo! From: Jeffrey W. Clemens (clemens@duq2.cc.duq.edu) Mon Nov 3 16:07:59 1997 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Bernard Cristalli: "Re: gyn oncology followup" Previous message: Malcolm Griffiths: "Re: Vitamin Supplements in Multiple Gestation" In reply to: rbraun@champion.iupui.edu: "Re: Age of Menopause--was HRT and the non-risk patient" Next in thread: R.Daniel Braun, MD FACOG: "Re: Age of Menarche By the Kilo!" Reply: R.Daniel Braun, MD FACOG: "Re: Age of Menarche By the Kilo!" Listers- Give the man a prize! My ref. at hand (Essential Reproduction, Johnson and Everitt, 4th ed.) give 47 kg as the magic number. For age at menarche, this was approx. at age 16 in a Belgian study (1835), age 14 in a American study (1895), and age 13 in 1959 (American or English). Menarche is a relatively late pubertal event. The adolescent growth spurt initiates at approximately 30 kg. Other supporting evidence is the amenorrhea in anorexics that drop below 47 kg and resumption above 47 kg (granted that anorexia nervosa may be a complicated, multi-factorial disease). The adipocyte product leptin may be the link. Defects in leptin and leptin receptor have been associated with infertility in rodents. Treatment with recombinant leptin can restore estrous cyclicity to animals with mutated leptin protein. Leptin, via its receptor, may regulate neuropeptide Y in the hypothalamus. NPY postulated to regulate GnRH. (sorry-no refs. handy at the moment. However, lots of info. re: leptin available on-line at the National Library of Medicine at the Online Mendelian Inheritance in Man database. I think that is at http://www.nlm.ncbi.gov. >The age of menarche has been lowered due to better nutrition. i.e. the >young lady reaches the magic weight of 100# at an earlier age and this >sets of the cascade at an earlier age. > >-- >R. Daniel Braun, MD -- ================================================================== Jeffrey W. Clemens, Ph.D. Assistant Professor Dept. of Biological Sciences Duquesne University Pittsburgh, PA 15282 412-396-4597 Fax 412-396-5907 ================================================================== Next message: Bernard Cristalli: "Re: gyn oncology followup" Previous message: Malcolm Griffiths: "Re: Vitamin Supplements in Multiple Gestation" In reply to: rbraun@champion.iupui.edu: "Re: Age of Menopause--was HRT and the non-risk patient" Next in thread: R.Daniel Braun, MD FACOG: "Re: Age of Menarche By the Kilo!" Reply: R.Daniel Braun, MD FACOG: "Re: Age of Menarche By the Kilo!"

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