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Re: Hormone replacement therapy and the non-risk patientFrom: Sorin Esanu (esanus@pcnet.pcnet.ro)Wed Oct 29 18:47:43 1997
>I don't know if this influences things but I was very disappointed to read >this in the BMJ which contradicts everything we think about HRT reducing the >risk of cardiac events. > ........... > Results: Data on cardiovascular events and cancer were usually given > incidentally, either as a reason for dropping out of a study or in a list > of adverse effects. The calculated odds ratios for women taking > hormones versus those not taking hormones was 1.39 (95% confidence > interval 0.48 to 3.95) for cardiovascular events without pulmonary ^^^^^^^^^^^^^^ > embolus and deep vein thrombosis and 1.64 (0.65 to 4.18) with them. It ^^^^^^^^^^^^^^ > is unlikely that such results would have occurred if the true odds ratio ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ > were 0.7 or less. For cancers, the numbers of reported events were ^^^^^^^^^^^^^^^^^^^ > too low for a useful conclusion. > > Conclusions: The results of these pooled data do not support the > notion that postmenopausal hormone therapy prevents cardiovascular > events. As I remember, if the confidence interval comes "across" value 1.00 as shown above, the OR (or RR) are NOT statistically significant because the real result can be ANYWERE inside the interval. So, I don't understand the point in comparing an established SIGNIFICANT OR with an unsignificant result !
-- ------------------------------------------------------------------- | Dr. Sorin Esanu | | ------------------------------------------------------------------- | medic specialist | e-mail:esanus@pcnet.pcnet.ro | ------------------------------------------------------------------- | obst & ginec | tel. hospital: +401 650 2047/283 | | IOMC - POLIZU | fax. hospital: +401 650 6146 | | Bucuresti - ROMANIA | | -------------------------------------------------------------------
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