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Re: Oral Methotrexate for GTN From: A.C. (A.C.Evans@m.cc.utah.edu) Thu Oct 9 13:09:13 1997 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Lynn Montgomery: "Premie Breech" Previous message: Samir Saidi: "Re: Vaginal dryness on OCPs" In reply to: Richard M. Chudacoff, MD: "Oral Methotrexate for GTN" On Mon, 6 Oct 1997 10:09:45 -0500, richardc@bcm.tmc.edu (Richard M. Chudacoff, MD) wrote: >22 yo G3P2 with invasive molar pregnancy, has missed multiple IV MTX >treatments, but after couseling states she will be 'reliable' to oral >treatment. Does anyone have an oral MTX regimen, either the 5 or 8 day >option, that they can send me publically or privately? > I would be hesitant to use oral MTX, as the absorption is somewhat unpredictable and saturable. Both poor compliance with IV therapy and use of oral therapy (which is much less reliable) would be prone to causing MTX resistance. Which regimen for MTX is she getting? Obviously high-dose MTX with folinic acid rescue would not be ideal since she is noncompliant and may develop fatal toxicity if she fails to take the folinic acid properly. Would she be open to weekly MTX (50 mg/sq. meter) IM or dactinomycin (1.25 mg/sq. meter) IV bolus q 2 weeks? A.C. Evans, M.D., Ph.D. Division of Gynecologic Oncology Univ. of Utah, Salt Lake City (801) 581-7640 A.C.Evans@m.cc.utah.edu acevans@hsc.utah.edu Next message: Lynn Montgomery: "Premie Breech" Previous message: Samir Saidi: "Re: Vaginal dryness on OCPs" In reply to: Richard M. Chudacoff, MD: "Oral Methotrexate for GTN"

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