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Re: Fosamax PLUS estrogen? From: George M. Grunert (grunert@ICSI.Net) Thu Jul 31 11:22:09 1997 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: George M. Grunert: "Re: Define infertility" Previous message: DoctorJoe@aol.com: "Re: Prior cesarean, SGA, need your help...." In reply to: Robert J. Woolley: "Fosamax PLUS estrogen?" > My sister-in-law, in her early 40s, asked me an interesting question the other > day; I just *know* that the definitive answer lies within the collective > knowledge and wisdom of this list. You're not going to find a definitive answer because MSD had not done (or reported) dual estrogen plus Fosamax studies. (Why pay to test your drug plus your competitor's and take the chance that you might recommend his instead of yours?) > It seems to me the question comes down to this: what is the difference in the > likelihood of developing clinically significant osteoporosis between women using > estrogen and calcium, versus those using estrogen, Fosamax, and calcium? My > hunch is that it's a pretty small difference, probably not worth 20+ years of > daily expensive drug use. A Medline search yielded no obviously relevant > references. Probably right - there's no current evidence that adding Fosamax to HRT, calcium, and exercise will further reduce the risk of osteoporosis. There's a pretty significant incidence of esophagitis in Fosamax users, so there should be a pretty good reason to use it to start with. FYI: The US FDA did just approve the use of 5mg Fosamax daily for prophylactic use in patients unable (usually translated as unwilling) to take ERT. Mac -- George M. Grunert, M.D. Director ART Program, Woman's Hospital of Texas 7550 Fannin Houston, TX 77054 713-512-7851 fax 713-512-7853 grunert@icsi.net Next message: George M. Grunert: "Re: Define infertility" Previous message: DoctorJoe@aol.com: "Re: Prior cesarean, SGA, need your help...." In reply to: Robert J. Woolley: "Fosamax PLUS estrogen?"

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