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Re: Premarin dose From: rbraun@indyunix.iupui.edu Tue Jul 22 06:52:21 1997 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: rbraun@indyunix.iupui.edu: "Re: Herbs" Previous message: rbraun@indyunix.iupui.edu: "Re: competency to consent" In reply to: MELISA ANNE GUILBEAULT: "Re: Premarin dose" Next in thread: rbraun@indyunix.iupui.edu: "Re: Premarin dose" On the other hand, patients with less weight have a smaller plasma volume and may need less total hormone to fill it up while conversely obese patients have a greater plasma volume and may need more hormone to fill it up. Combine this with the greater conversion of androgens to estrogens in obese people and the two might cancel each other out and everybody would need the same dose. Who Knows ?? The Shadow Knows! But he ain't talkin! This would make a great research project for someone. -- @@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@ R. Daniel Braun, MD FACOG "Money will buy you a fine dog Clinical Professor OB/GYN but only love will make it Indiana University School of Medicine wag its tail" Indianapolis, IN Richard "Kinky" OBGYN.net, International Rep. U.S. Friedman Kinky Friedman for President @@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@ On Mon, 21 Jul 1997, MELISA ANNE GUILBEAULT wrote: > > > Should the premarin dose vary based on patient's weight? Body mass index? > > Body fat percentage? > > Julie Graves Moy, MD, MPH > > Austin, Texas > > Hi, > > You would think it would, since women who have less body fat > would convert less androstendione to estrone, and testosterone to > estradiol, peripherally, and would therefore be at greater risk > for developing osteopersosis. So for such patients you would 'think' > a higher dose of Estrace/Premarin would be applicable. But I have > never seen a study or a recommendation for the use of some sort of > an index . . . . I only know for a fact that women who have less body > fat are at greater risk for developing osteoperosis in their > postmenopausal years, because of their greater lack of extragonadal > aromatization. > > Personally I would grade individuals based on ectomorphy, mesomorphy, > and endomorphy, in descending order, for need, with a body fat > percentage calculation - for a study that is. > > & most just prescribe 0.625-1.25 mg/day would thinking. Estrace > (micronized 17-beta estradiol) does not come from horse urine, is > cheap, and is equivalent to premarin peripherally, and @ the > endometrium, at in ratio of 0.625 mg/d of Premarin - to - 1 mg/d of > Estrace OR 1.25 mg/d of Premarin - to - 2 mg/d of Estrace > > Anyone else??? > > -Melisa > Next message: rbraun@indyunix.iupui.edu: "Re: Herbs" Previous message: rbraun@indyunix.iupui.edu: "Re: competency to consent" In reply to: MELISA ANNE GUILBEAULT: "Re: Premarin dose" Next in thread: rbraun@indyunix.iupui.edu: "Re: Premarin dose"

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