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Re: Premarin doseFrom: MELISA ANNE GUILBEAULT (maguilbe@Ice.Lakeheadu.Ca)Mon Jul 21 12:48:57 1997
> Should the premarin dose vary based on patient's weight? Body mass index? > Body fat percentage? > Julie Graves Moy, MD, MPH > Austin, Texas Hi, You would think it would, since women who have less body fat would convert less androstendione to estrone, and testosterone to estradiol, peripherally, and would therefore be at greater risk for developing osteopersosis. So for such patients you would 'think' a higher dose of Estrace/Premarin would be applicable. But I have never seen a study or a recommendation for the use of some sort of an index . . . . I only know for a fact that women who have less body fat are at greater risk for developing osteoperosis in their postmenopausal years, because of their greater lack of extragonadal aromatization. Personally I would grade individuals based on ectomorphy, mesomorphy, and endomorphy, in descending order, for need, with a body fat percentage calculation - for a study that is. & most just prescribe 0.625-1.25 mg/day would thinking. Estrace (micronized 17-beta estradiol) does not come from horse urine, is cheap, and is equivalent to premarin peripherally, and @ the endometrium, at in ratio of 0.625 mg/d of Premarin - to - 1 mg/d of Estrace OR 1.25 mg/d of Premarin - to - 2 mg/d of Estrace Anyone else??? -Melisa
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