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Re: BR CA 1 testing From: Harvey S. Marchbein, M.D. (hmarchbein@worldnet.att.net) Mon Jun 30 20:25:04 1997 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Robert Brenner: "Re: Computerized Prenatal Record." Previous message: Robert J. Woolley: "summary of Prenatal Care Meeting (fwd)" In reply to: Robert J. Woolley: "Re: BR CA 1 testing" Next in thread: ATB28@aol.com: "Re: BR CA 1 testing" At Fri, 27 Jun 97, Robert J. Woolley wrote: > >In message <199706280326.WAA13772@talk.obgyn.net> writes: >> >> What do ya'll think? > >I am not yet convinced that the test has a high enough positive predictive value >to be relied on for this decision. Bob, The Brca 1 has an 80% predictive value for breasrt cancer and 60% for ovarian cancer giving an overall cancer rate of approximately 100%. A mutation of this gene occursw in 1% of Ashkenazi women. The Brca 2 gene mutations occur in 0.5% of Ashkenazi women and the rate of breast cancer is also 80% with the rate of ovarian cancer being less than the above noted 60% (sorry can't remember the number..it's at the office and I'm at home). There are multiple papers on these stats and anyone of them via a Medline search will convince a true scientific mind. If not, you'll just have to hang around more Ashkenazi women ;-) -- Harvey Harvel the Marvel Harvey S. Marchbein, M.D. FACOG, FACS President, Nassau Obstetrical and Gynecological Society, Inc. OBGYN.net U.S. Representative, New York http://www.obgyn.net/states/bios/marchbein.htm Private practice, Long Island, N.Y. ********************************* It's better to be lucky than to be smart. Even smart people can have an off day! ********************************* Next message: Robert Brenner: "Re: Computerized Prenatal Record." Previous message: Robert J. Woolley: "summary of Prenatal Care Meeting (fwd)" In reply to: Robert J. Woolley: "Re: BR CA 1 testing" Next in thread: ATB28@aol.com: "Re: BR CA 1 testing"

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