Re: GNRH agonists and adenomyosis

From: Harvey S. Marchbein, M.D. (hmarchbein@worldnet.att.net)
Mon Mar 31 19:12:34 1997


At Mon, 31 Mar 1997, Richard Chudacoff, MD wrote:

>My scope showed a normal pelvis, no evidence of endometriosis nor adhesions,
>with bilateral flow through the normal appearing fallopian tubes. Her uterus
>is slightly enlarged and globular.

>Okay, here is the question. I believe she has adenomyosis, and I know she
>wants to wait a year into her marriage before she gets pregnant. There are a
>couple of reports about using GNRH agonists with adenomyosis for pain
>control. Anyone out there have experience with this management, assuming
>that paragraph 2 does not work? My thought is to use the GNRH agonist solo
>for three months and if there is relief, then start with add back therapy
>with the highest possible dose that does not cause a return of the pain.
>Whatjathink?

Only experience with GnRH agonists is with endometriosis and fibroids so I can't help there, but, two points.

With chronic pelvic pain, I always consider sexual abuse at a younger age as a possible cause when she scopes negative.

If all else fails, consider uterosacral nerve ablation. I've had modest (read 50/50) success with this approach.

--
Harvey

Harvel the Marvel Harvey S. Marchbein, M.D. FACOG, FACS President-elect Nassau Obstetrical and Gynecological Society, Inc. OBGYN.net U.S. Representative, New York http://www.obgyn.net/states/bios/marchbein.htm Private practice, Long Island, N.Y. ********************************* It's better to be lucky than to be smart. Even smart people can have an off day!

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