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Re: Calcitonin and Estrogen From: Arthurfree@aol.com Fri Mar 14 00:14:01 1997 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Birthctr@aol.com: "Re: pruritus" Previous message: douglas krell: "Re: Interval Sterilization" Maybe in reply to: Richard Chudacoff, MD: "Calcitonin and Estrogen" Next in thread: Gibbons,John: "Re: Calcitonin and Estrogen" Please see portions of forwarded messages below. Calcitonin, estrogen, AND bisphosphonates (alendrolate and etidronate) all interfere with osteoclast function, and do so by somewhat different mechanisms. The data is minimal on what combining any of them will do. (please see very recent post on article from AJM which is the only thing I could find on combination therapy) Arthur Freeland Warrensburg Missouri > >At Thu, 13 Mar 1997, Jeffrey W. Clemens wrote: > >>Summary on estrogen action from same: >> Estrogens are major inhibitors of osteoclast formation (remember >>that osteoclasts are multi-nucleate from uninucleate precursors) and are >>ER+. Exact mechanism still unclear and may involve cytokines, >>prostaglandins, etc.. Estrogens in vitro can promote apoptotic cell death >>of cultured osteoclasts. Bisphosphonates (synthetic analogs of >>pyrophosphate; Fosamax) interfere with osteoclast ruffled border formation >>and appear to bind to bone hydroxyapatite, inhibiting resorption of same >>(this is in part from product lit. for Fosamax). > >Unless I misunderstand the info above (which is entirely possible >considering my vacation starts Saturday), it sounds like ERT and Fosamax >might complement each other. If anyone understands differently, and is >willing to crush me just prior to vacation time, go for it ;-) > >-- >Harvey > >Harvel the Marvel Next message: Birthctr@aol.com: "Re: pruritus" Previous message: douglas krell: "Re: Interval Sterilization" Maybe in reply to: Richard Chudacoff, MD: "Calcitonin and Estrogen" Next in thread: Gibbons,John: "Re: Calcitonin and Estrogen"

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