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Re: abnl triple screenFrom: J. Hellriegel (jhellrie@pce.net)Thu Mar 6 18:54:42 1997
At Wed, 5 Mar 1997, Snorklesue@aol.com wrote: > >Dear List, >Since we're talking about triple screen, what do you quote your pts as false >positive rate of triple screen for Down's syndrome? Are there references to >this? > >Susan Lee, MD >Womack Army MedCen Do not think of the triple screen as being false positive or false negative. A "positive" triple screen simply means that when the results of the three tests adjusted for age and weight of the patient are pluged into a formula the results indicate that the risk for Down's Syndrome are greater than those expected for a women who is 35 years old. In addition to reporting the test as "positive" my laboratory also reports the calculated statistical probability that the baby will have Down's. For example the age related risk may be 1/231 while the risk calculated from the triple test is 1/19. The increased risk of 1/19 is justification for aminocentesis and chromosomal analysis. In this case the statistical probability that we will find Down's is 1/19 and the probability that we will not is 18/19.
-- J. Hellriegel, Jr., MD, PhD
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