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Re: potential teratogenic exposures from sexual relations?From: Arthurfree@aol.comWed Jan 1 13:55:43 1997
In a message dated 96-12-30 22:53:24 EST, Bryan Jick writes:
> To answer the question you didn't ask: prostatitis in young males is more commonly due to Chlamydia and other non cell wall organisms (ureaplasma, ?mycoplasma) than to urinary pathogens, so my major concern with this history would be to reculture her or even treat empirically with a macrolide.
> I figured I'm not certain any medication appears in very high concentration in the seminal fluid, we have to use significant doses of agents with fairly low MIC's to achieve prostatic/epididymal cures.
>My next thought...what if the spouse were on a highly teratogenic agent such Good question. I rather doubt that vaginal absorption of any of the above agents would be very significant, this combined with the extremely low concentration of these agents in seminal fluid in the first place would make it likely that the blood levels achieved would be extremely low, so the question would become how much exposure could be generated by direct flow to the uterine cavity. With the low rate of proximal infection with even significant exposure to pathogens in pregnancy, I would suspect that the proximal flow of seminal fluid is negligible.
>Bryan Jick, M.D. Arthur Freeland, MD Warrensburg Missouri
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