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Q feverFrom: Terrence.Jones@ncal.kaiperm.orgFri Nov 29 14:04:34 1996
Cheri, self limited Q fever probably not much of a threat other than the usual febrile risks. The problem arises with chronic infection, fairly rare in pregnancy, and involving endocarditis, granulomatous hepatitis, and osteo- myelitis. When this occurs, it is felt to be related to chronic placentitis (Clin Inf Dis 11/95, 21:1318-21), and demonstrates the apparent 'predilection' of the organism for the placenta. This study specified 'human' placenta, however there appears to be a generic proclivity for eutherians - see J. Fam Practice 12/92, 35:683-5: an outbreak in a lab utilizing sheep placentae for study. Also, a case from around '92 of a woman contracting the illness from a parturient cat (!). Descending down the food chain a bit further, lab mice studies have demonstrated the lesion (Inf. Immunol 12/92, 60: 5232-41) with reference to placental necrosis, fibrinoid degeneration of decidual vessels, and microthrombosis. I suppose that, should Dr. Machin find such changes, a more careful postpartum surveillance protocol might be adopted. T.Jones/KSF.
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