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Re: 800 mg acyclovirFrom: Mats Bergstrom (matsb@cor.sos.sll.se)Wed Nov 13 04:07:38 1996
On Tue, 12 Nov 1996, Robert J Woolley wrote:
> outbreaks of both oral and genital herpes can be prevented by a single
I agree that without a control group (and a double blind protocol)
a study like this is not proving anything. On the other hand, it
cannot be dismissed out of hand as not pointing to a real phenomenon.
>From scanning abstracts on the subject since 1986 this is hard to Most studies since 1986 compare episodical to continuous treatment for recurrent herpes genitalis and find the continuous protocol far superior. But the usual dosage of episodical treatment to compare to is 200mg x 5, which does not rule out a better effect of a single 800mg dose. And Whatley et al (Journal of Antimicrobial Therapy 1991;27(5):677-81), comparing two regimens of episodical treatment, found 400mg x 2 to be somewhat more efficient than 200mg x 5 regarding complete suppression of symptoms (60% versus 44% but most probably not significant). But Goldberg et al (Am J of Medicine 1988;85(2A):10-3), comparing 800mg x 2 to 200mg x 5 (episodical) did not find any difference in women (but a tendency in favor of 800mg x2 in men).
-- Mats Bergstrom, MD Ob Gyn South Hospital Stockholm
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