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Re: 800 mg acyclovirFrom: Gordon M. Goldman (gmgoldman@sprintnet.com)Tue Nov 12 17:10:42 1996
Robert J Woolley wrote: > > One of my partners gave me a photocopy of a single-page article from a > throw-away journal (it doesn't say which one), June 1996. The authors > claim, on the basis of 32 patients (no control gorup) that impending > outbreaks of both oral and genital herpes can be prevented by a single > dose of acycolvir 800mg at the first hint of symptoms: 26 totally > prevented, 2 partially prevented, 4 no protection. They give no footnotes > to previously similar research. > > Has anybody else tried this? I'm awfully skeptical on several grounds. > First, they would surely publish in a better journal if they could. > Second, any open trial without a control group is highly suspicious, > since there's no way of telling how many really were about to have an > outbreak, and no control of placebo effect. Third, on theoretical > grounds, I have a hard time believing that a single dose would be that > effective in shutting down viral replication. > > Comments?I think that is why they are called "throw away" journals. Gordon -- Life is a sexually transmitted disease and is inevitably fatal. (Borrowed)
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