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800 mg acyclovirFrom: Robert J Woolley (wooll005@gold.tc.umn.edu)Tue Nov 12 16:09:49 1996
One of my partners gave me a photocopy of a single-page article from a throw-away journal (it doesn't say which one), June 1996. The authors claim, on the basis of 32 patients (no control gorup) that impending outbreaks of both oral and genital herpes can be prevented by a single dose of acycolvir 800mg at the first hint of symptoms: 26 totally prevented, 2 partially prevented, 4 no protection. They give no footnotes to previously similar research. Has anybody else tried this? I'm awfully skeptical on several grounds. First, they would surely publish in a better journal if they could. Second, any open trial without a control group is highly suspicious, since there's no way of telling how many really were about to have an outbreak, and no control of placebo effect. Third, on theoretical grounds, I have a hard time believing that a single dose would be that effective in shutting down viral replication. Comments?
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