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Re: Duchene muscular dystrophyFrom: Allen Gardner (allen.gardner@utoronto.ca)Wed Nov 6 19:35:06 1996
I suggest that before embarking on fetal muscle biopsy that the sex of the fetus be determined. If it's a girl, she will not be a "patient". If a male, then you can approach the patient about muscle biopsy. Perhaps someone can tell me how reliable the dystrophin staining is in predicting DMD in a fetus. Allen.
-- Allen Gardner MD Genetics Oshawa General Hospital Oshawa, Ontario, Canada ==================================================== > If your patient wants the fetus checked testing by muscle biopsy is available > if DNA analysis would not be diagnostic. For DNA testing I would suggest > someplace like Baylor or Integrated Genetics. Muscle biopsy has been performed > multiple times at UCSF, Detroit, and we could do it. Testing of the muscle > biopsy by histology and staining for dystrophin has traditionally been done in > the Hoffman lab (I believe in Pennsylvania) but there may be others performing > it now. > > I have probably overburdened you with details but let me know if this helps or > you need more info. I'm sure you will hear from others. > > Jerome Yankowitz, MD > Univ of Iowa Hosp and Clinics > Maternal-Fetal Medicine and Clinical Genetics
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