Re: Chicken Pox exposure 1st tri

From: Terrence.Jones@ncal.kaiperm.org
Fri Oct 25 23:35:21 1996


"Every morning is the dawn of a new error" :) Have to agree with Jimmy, "1 gram" of VZIG probably is NOT of any benefit, at least from a proper dosing perspective. The dose of VZIG post-varicella expos. prophylaxis is 125 UNITS/10kg to a max of 625 UNITS. Most pregnant pts will weigh more than 50 kg, and so would receive the 625 max dose. Each dose comes in a 125 UNIT vial, with a volume of 2.5 cc, so most pregnant pts will require 5 vials. Remember, only ONE vial (2.5 cc) at each deep IM injxn site (ouch!). Best to arrange injections OUTSIDE labor & del suite to avoid introducing incubating varicella here. The 97 pts (all trimesters) given THERAPEUTIC post- exposure prophylaxis (within 96 hrs), who later developed rash, showed no evidence of congenital varicella in their newborns. Of the 472 FIRST trimester infections recorded in the Joint Prospective Study conducted between the UK & Germany from 1980-93, in whom there was NO antecedent postexposure prophyl- axis, there were two reported cases (0.4%) of congenital varicella. (Lancet 6/94, vol 343: 1548-51). The highest risk (2.0%) of cong varicella occurred following exposure at 13-20 wks (7 affected infants in 351 pregnancies). Sorry for not paying closer attn to the dose reported (?1GRAM?), jus' sorta' assumed... Hmmmmm...So what IS the mol wt of oxytocin? Terry Jones KSF :) ~~ --------------------------( Forwarded letter 1 follows )--------------------- Date: Friday, 25 October 1996 5:51pm --------------------------( Forwarded letter 1 follows )--------------------- From: J J Walker <msjjjw@gps.leeds.ac.uk> --------------------------( Forwarded letter 1 follows )--------------------- Subject: Re: Chicken Pox exposure 1st trimester Sender: ob-gyn-l@listserv.bcm.tmc.edu To: Multiple recipients of list <ob-gyn-l@listserv.bcm.tmc.edu> Errors-to: gklein@bcm.tmc.edu Reply-To: ob-gyn-l@listserv.bcm.tmc.edu Precedence: bulk Originator: ob-gyn-l@listserv.bcm.tmc.edu X-Comment: List for the discussion of obstetrics and gynecology X-Listprocessor-version: 6.0c -- ListProcessor by Anastasios Kotsikonas

>Doc checks for Ab's, finds none and gives 1g VZIg.

This is of no benefit.

After active disease, the risk to her baby is around 1/100. A normal scan may reduce this. I see no difference in the second senario.

Jimmy Professor James Walker, Department of Obstetrics and Gynaecology, St James University Hospital Beckett Street, LS9. Tel: 0113 283 6864 FAX: 0113 234 3450 Email: msjjjw@gps.leeds.ac.uk





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