Tamoxifen and endometrial changes
From: John Hellriegel (jhellrie@pce.net)
Mon Oct 7 20:33:47 1996
>Date: Wed, 02 Oct 1996 13:04:19 -0400
>From: "Garry E. Siegel" <garrys@atl.mindspring.com>
>Subject: Tamoxifen and endometrial changes
>
>(Would screen this patient for osteoporosis.)
>Why ? Asks Malcolm Griffiths.
Because the patient is on long term therapy with a progestin, Megace.
I suggested continuous, not cyclic, therapy with Megace.
I am aware that some have suggested that the “anti-estrogenic”
effect of progestins on bone mineralization decreases over time,
but I would error on the side of caution and screen for osteoporosis.
If this patient has Stage I breast cancer and is postmenopausal, she
has a high probability of long term survival.
I am not aware of any study demonstrating that Tamoxifen
is as effective as estrogen at preventing osteoporosis.
I agree with and appreciate your point that Tamoxifen has a positive
impact on bone mineralization.
--
John Hellriegel, Jr., MD, PhD
Buffalo, NY
jhellrie@pce.net
