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Beta-mimetics>48h ( was No Subject )From: Malcolm Griffiths (Malcolm@mgriff22.demon.co.uk)Wed Jul 24 16:56:02 1996
In message <960724093213_440778455@emout12.mail.aol.com>, DoctorJoe@aol.com writes ><<Several of you asked what do I do after 48 hours of indomethacin and the >"patient is still contracting". > >My first question is whether she is changing her cervix. There is simply >NO DATA that ANY tocolytic works for longer than 48 hours. The era of >evidence-based medicine has arrived. IN fact, I believe we do our >patient's a disservice to place them on self-controlled terbutaline pumps >at $1000/week so that we can simply down-regulate their beta receptors. >The infamous pump has never been evaluated in a randomized trial despite >its widespread use. I applaud the consumer group that is seeking to have >us re-examine these costly unproven therapies. > >Ken Moise>> > >So Ken... the original question was, what do you do after 48 hours? Say the >contraction frequency is lower, but at 48 hours, you stop your indomethacin >and she starts contracting again and her cervix starts to change? I believe >someone asked you whether you call this a "new" episode and start over, or >continue what you already had. > >Joe P. > >P.S. I really didn't want to get into the "NO DATA...48 hours" discussion; >most RCTs, like the Canadian ritodrine study, are so bad that I think it is a >true statement that there is really no data that tocolytics DO NOT work >longer than 48 hours. Totally agree. IT'S THE STEROIDS THAT COUNT !!! ps. Can we please use suject lines that give us a clue to the contents - NO SUBJECT - I ask you ?!:-)
--
Malcolm Griffiths MD,MRCOG,MFFP,Cert.Mgmnt
Obstetrician & Gynaecologist Luton & Dunstable Hosp.,UK.
Tel: 01582-497459 (office)
01525-222849 (home)
Fax: 01582-497424
email: Malcolm@mgriff22.demon.co.uk
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