Re: Trisomy 9

From: Allen Gardner (allen.gardner@utoronto.ca)
Wed Jun 12 11:18:21 1996


Trisomy 9 is pretty rare. I wouldn't be inclined to suggest an increased recurrance risk, unless you believe that meiotic non-disjunction of one chromosome increases the risk of non-disjunction in others. This has been shown for chrom 21 but it hasn't been shown for other chroms. However I would offer MSS and have a thorough discussion of risks and benefits of amnio. I would make amnio and/or level 2 available but I think this would be a reassurance exercise. Allen.

H. Allen Gardner MD Genetics Oshawa General Hospital 24 Alma Street Oshawa, Ontario L1G 2B9 ================================================ On Wed, 12 Jun 1996 09:44:48 -0400 DoctorJoe@aol.com wrote:

> From: DoctorJoe@aol.com> Date: Wed, 12 Jun 1996

09:44:48 -0400 > Subject: Re: Trisomy 9
> To: Multiple recipients of list
<ob-gyn-l@listserv.bcm.tmc.edu> >
> <<27 yo G2 P0101 currently 13+ weeks whose history is

significant for her > first child carrying the diagnosis of Trisomy 9
(mosaic). She and her husband > (also the biological father of the affected child)

have had normal > karyotypes.>>
>
> Isn't the risk of aneuploidy in this situation about

3% or so? I would say > that is greater than the "quoted" 1/200 risk of

amnio... >
> Joe P.





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