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Re: MACS etc From: T-H Bui, Clinical Genetics, Karolinska Hospital (bui@gen.ks.se) Thu May 30 06:24:21 1996 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: T-H Bui, Clinical Genetics, Karolinska Hospital: "Re: twins" Previous message: T-H Bui, Clinical Genetics, Karolinska Hospital: "Re: ultrasound in Holland" Maybe in reply to: Joshua Copel: "MACS etc" At 14.14 1996-05-29 -0500, Joshua Copel wrote: > Subject: Time: 10:36 AM > OFFICE MEMO MACS etc Date: 5/29/96 > >>Charlie Chambers wrote: "The group most experienced with MACS would be from >Germany. I would suggest you contact Wolfgang Holzgreve regarding this >issue at the University of Muenster." > >There are two groups funded in the US for fetal cells in maternal circulation. >One is at Tufts, with Diana Bianchi. I am not sure of the other, maybe UCSF. I >assume we will see a post from Ken Moise if it is Baylor. Wolfgang Holzgreve >recently moved to Basel, the Universitats-Frauenklinik. My understanding from >Diana is that MACS is less expensive & easier to perform than FACS, but purifies >less well, and neither really creates pure fetal samples, just improved >concentrations by several orders of magnitude. That still leaves concentrations >on the order of one fetal cell in 10 to the 8th or 9th power maternal cells. As a matter of facts there are more groups in the US funded by NICHD for the isolation of fetal cells in maternal blood for prenatal diagnosis: Baylor CM (Sherman Elias as PI), Jefferson MC, Tufts University/New England MC (Diana Bianchi as PI), Wayne State University/Basel (Mark Evans as PI), and Integrated Genetics, Framingham, MA (Klinger as PI). At this stage of the study, I doubt that any groups will share in some details their results & techniques before the end of the study due to October 1997. In Europe, apart from the Basel group (Holzgreve, Gänshirt-Ahlert), there are major groups in Helsinki, Nottingham (L.Durand & D. Liu), Leeds (D. Miller) although studies have been done in other centers including ours. ***************************************************************** The-Hung Bui, M.D. =20 Associate Head Physician =20 -- Department of Clinical Genetics Karolinska Hospital S-171 76 Stockholm, Sweden phone: +46 8 729 4989 or 729 2472 (secretary) fax: +46 8 32 77 34 E-mail: bui@gen.ks.se or The-Hung.Bui@molmed.ki.se ****************************************************************** Next message: T-H Bui, Clinical Genetics, Karolinska Hospital: "Re: twins" Previous message: T-H Bui, Clinical Genetics, Karolinska Hospital: "Re: ultrasound in Holland" Maybe in reply to: Joshua Copel: "MACS etc"

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