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Re: Dimeric Inhibin-A and Down's Syndrome From: T-H Bui, Clinical Genetics, Karolinska Hospital (bui@gen.ks.se) Tue May 28 10:40:14 1996 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: T-H Bui, Clinical Genetics, Karolinska Hospital: "Re: fetal cells in maternal blood" Previous message: Jozef Zahumensky: "Re: gloves use" Maybe in reply to: Geffrey H Klein, MD: "Dimeric Inhibin-A and Down's Syndrome" At 16.22 1996-05-27 -0500, Geffrey H Klein, MD wrote: >Did anyone read the NEJM article on Inhibin-A and Down's Syndrome: > >Dimeric Inhibin A as a Marker for Down's Syndrome in Early >Pregnancy by Aitken, etal >(N Engl J Med 1996;334:1231-6.) > >Conclusion: elevated Inhibin-A in combination with maternal age, hcg, >and AFP level increased detection rate of Down's to 75% from 53% >versus the above without Inhibin-A. Did I miss something, >or have we stopped using unconjugated estriol? No you did not miss anything. The 'triple test' in routine use still comprised uE3. However, scientists are still looking for better biochemical markers for aneuploidy. The interest now is focused to the first trimester of pregnancy where PAPP-A has been shown to have about the same power as free beta-hCG in the second trimester for Down syndrome. Other investigators are even looking at maternal urine (beta core-hCG) in the first trimester but this is still very investigative. At a meeting in Amsterdam at the beginning of this month biochemical serum and other markers of aneuploidy were discussed. Dr Sherman Elias from Baylor attended the meeting and gave (of course) a lecture about fetal cells in maternal blood for prenatal diagnosis. You may asked him to update you or borrow the proceedings of the meeting. ***************************************************************** The-Hung Bui, M.D. Associate Head Physician -- Department of Clinical Genetics Karolinska Hospital S-171 76 Stockholm, Sweden phone: +46 8 729 4989 or 729 2472 (secretary) fax: +46 8 32 77 34 E-mail: bui@gen.ks.se or The-Hung.Bui@molmed.ki.se ****************************************************************** Next message: T-H Bui, Clinical Genetics, Karolinska Hospital: "Re: fetal cells in maternal blood" Previous message: Jozef Zahumensky: "Re: gloves use" Maybe in reply to: Geffrey H Klein, MD: "Dimeric Inhibin-A and Down's Syndrome"

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