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Re: Prenatal rhogam Qs... From: "Francisco L. Romero Aceña" (fromero@adam.es) Tue May 21 14:38:26 1996 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: "Francisco L. Romero Aceña": "Re: palpation after VBAC" Previous message: Jason Gardosi: "Re: OB-GYN-L digest 517" Maybe in reply to: MS GAIL M HART: "Prenatal rhogam Qs..." In our group, we think exactly as Dr Berstein but we give it to all women Rh neg because has been demonstrated that, in our country, about 7% of Rh negative women with Rh neg husband have Rh positive fetuses. Please , don't tell me, I know it is biologycally impossible but i speak about husbands not about fetuses'fathers. Excuse my bad English. >We give full dose (300ug) Rhogam to all Rh negative women whose partners are >Rh positive or unknown at 28 weeks. This is based primarily on the work of >Zipursky in Manitoba. He first demonstrated that the presence of fetal cells >in the maternal circulation is a very common event during pregnancy and that >the volume of exchange needed to create sensitization was as little as 1.3 >cc.(1) He later demonstrated that between 1 and 2 % of all women who undergo >Rh sensitization do so in their first pregnancy.(2) Since his work it has >become clear that fetal maternal bleeds even smaller than 1.3 cc. can >provoke a maternal immune response and the factors controlling the level of >sensitivity to the Rh positive cells is not completely known.(3) > >1. Zipursky A, Pollack J et al The Lancet 1963 September 7 page 489-93 >2. Davey MG, Zipursky A Vox Sang 1979:36 page 50 >3. Branch DW Scott JR Isoimmunization in pregnancy in Gabbe (eds) normal and >problem pregnancies 2nd edition page 957-992. >IRA > >Ira M. Bernstein M.D. >Department of OB\GYN >University of Vermont >(802) 656-5111 (ph) >ibernste@moose.uvm.edu > -- --------------------------------------------- Francisco L. Romero Hospital General de Catalunya. --------------------------------------------- fromero@adam.es --------------------------------------------- http://webs.adam.es/fromero/myweb.htm BARCELONA (Spain) Next message: "Francisco L. Romero Aceña": "Re: palpation after VBAC" Previous message: Jason Gardosi: "Re: OB-GYN-L digest 517" Maybe in reply to: MS GAIL M HART: "Prenatal rhogam Qs..."

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