Use of Rhogam

From: Hellriegel, John (jhellrie@ubmedd.buffalo.edu)
Fri May 17 21:03:31 1996


Subject: Re: Prenatal rhogam Qs...

"No one has mentioned it yet, but I assume rhogam is being given at the time of amnio as well. Allen."

I think that giving rhogam at the time of amnio is routine. As I recall, the half life of rhogam is about 6 weeks and that you should repeat the rhogam after 2 half lives (12 weeks). I believe the rational was that if the antibody level became very low, the antibodies somehow augmented the sensitization of the mother. Thus, for an amnio at 16 weeks the repeat dose would be at 28 weeks.

What about an early amino at 12 weeks? Should rhogam also be given at about 24 weeks and 36 weeks?

Comments from the experts?

John Hellriegel jhellrie@ubmedd.buffalo.edu





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