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Re: Enhancing fetal lung maturi From: John Robertson (jgmr@unixg.ubc.ca) Mon Apr 29 09:36:50 1996 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: SAVARIS@vortex.ufrgs.br: "Re: clomid and single shot pergonal for first line obgyn's" Previous message: Douglas Krell: "Re: ankylosing spondylitis and ..." Maybe in reply to: Joshua Copel: "Enhancing fetal lung maturi" Next in thread: R L Meisel: "Re: Enhancing fetal lung maturi" Joshua is of course right. I did mean IM, not PO. However the usual doing interval around here is 12 hours, not 24; and it is usually 12 mg. -- ---------- From: Joshua Copel[SMTP:joshua.copel@yale.edu] Sent: Friday, April 26, 1996 1:53 AM To: jgmr@unixg.ubc.ca Subject: Enhancing fetal lung maturi Subject: Time: 9:41 AM OFFICE MEMO Enhancing fetal lung maturity Date: 4/26/96 John Robertson wrote: "I suggest dexamethasone 12mg po q12h for 2 doses. I believe that is the NIH recommendation." The NIH Consensus panel recommended either 12 mg betamethasone, a long acting form of steroid, 2 IM doses 24 hours apart, or 6 mg dexamethasone 4 doses IM at 12 hour intervals. There is no mention of oral doses. Clear benefits occur by 24 hours, and our practice is to give them to all candidates unless delivery is imminent (next few minutes). The Consensus panel report is NIH publication 95-3784. I do not know if it is on the Web, but there sure is a lot at http://www.NIH.GOV. Jozef Zahumensky asked about "I have read something about treatment of RDS with praepartal giving tyroxin or TRH. I'm interested about your's experiences. Thank's." We use TRH (thyrotropin releasing hormone) 400 micrograms IV every 8 hours for 4 doses based on Ballard's work (Lancet 1992;339:510-515), and previous work quoted in that paper. A more recent Lancet paper failed to show benefits, but used a lower dose of TRH. Because of possible adverse effects of TRH we only use it for micropreemies (before 27-28 weeks), and only a single course. Josh Copel Yale Ob-Gyn, MFM Joshua.Copel@Yale.edu Next message: SAVARIS@vortex.ufrgs.br: "Re: clomid and single shot pergonal for first line obgyn's" Previous message: Douglas Krell: "Re: ankylosing spondylitis and ..." Maybe in reply to: Joshua Copel: "Enhancing fetal lung maturi" Next in thread: R L Meisel: "Re: Enhancing fetal lung maturi"

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