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Re: Gadolineum in early pregnancyFrom: YankowitzJ@obgyn-po.obgyn.uiowa.eduSun Apr 28 14:16:30 1996
Mitch,
>Anyone with any experience or knowledge about MRI with contrast(gadolineum) Reference below is the only one I could find. I would look into clearance of this agent before recommending TAB 1. Barkhof F, Heijboer RJ, Algra PR: Inadvertent i.v. administration of gadopentetate dimeglumine during early pregnancy [letterŲ. Am J Roentgenol 158: 1171, 1992.
>contrast enhanced MRI at what was about 1 week post Unless there is long term binding of gadopentetate or kinetics of clearance are very slow I would think that the agent would be cleared by the start of the classical teratogenic risk period which is about 30-35 days to 70 days post LMP or one week or more beyond your patients exposure if dating is correct. I would bet (only a few cents) that the patient's risk from her seizure disorder and any meds that she is on for that far outweigh the risks of the contrast agent. Just my humble opinion. Good Luck! Jerry Yankowitz, MD MFM & Clinical Genetics Univ of Iowa Hospitals and Clinics
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