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Re: gossypol for endometriosis in India From: Mark Perloe (mperloe@ivf.com) Fri Apr 26 21:19:42 1996 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Peter V. Weston, M.D.: "Re: need help with weird case." Previous message: mark decker: "clomid and single shot pergonal for first line obgyn's" Maybe in reply to: Mark Perloe: "gossypol for endometriosis in India" These citations were interesting thought you would find them interesting. National Library of Medicine: IGM Selected Full Records Screen [Help] [infosearch] [backfiles] [Log off IGM] [Return to Results] [Return to Search] --------------------------------------------------------------------------- Full Citations: 1 to 5 of 5 from 1985-89 --------------------------------------------------------------------------- --------------------------------------------------------------------------- -- --------------------------------------------------------------------------- TITLE: [Clinical effects and experimental study on gossypol in endometriosis] AUTHOR: Xu LF; Wang M; Zhao CL SOURCE: Chung Hsi I Chieh Ho Tsa Chih 1989 Aug;9(8):462-4, 451 NLM CIT. ID: 90090781 ABSTRACT: Effects of the gossypol on endometriosis in 12 cases of control were observed. The results showed that the gossypol administered orally was effective in endometriosis patients. The basal body temperature changed from biophase to monophase. Dysmenorrhea disappeared in 11/12 patients. Amenorrhea occurred in 10/12 patients and the ovarian endometrial cyst was shrinkable. Serum progesterone and estradiol were decreased after gossypol administration, but follicle-stimulating hormone and luteinizing hormone were increased evidently. Histochemical and cytochemical observations revealed that the activity of acid phosphate (ACP), nonspecific esterase (NSE) and alkaline phosphate (AKP) in both aberrant uterine endometrium and uterine endometrium in situ were decreased evidently. The above results suggest that the satisfactory therapeutic effect of gossypol on endometriosis may be due to not only the indirect but also the direct action on uterine endometrium. MAIN MESH Endometriosis/*DRUG THERAPY SUBJECTS: Gossypol/*ANALOGS & DERIVATIVES/THERAPEUTIC USE Uterine Neoplasms/*DRUG THERAPY ADDITIONAL Adult MESH SUBJECTS: Antineoplastic Agents, Phytogenic/THERAPEUTIC USE Drugs, Chinese Herbal/THERAPEUTIC USE English Abstract Female Human Middle Age Ovarian Neoplasms/DRUG THERAPY PUBLICATION JOURNAL ARTICLE TYPES: LANGUAGE: Chi REGISTRY 0 (Antineoplastic Agents, Phytogenic) NUMBERS: 0 (Drugs, Chinese Herbal) 12542-36-8 (gossypol acetic acid) 303-45-7 (Gossypol) -------------------------------------------------------------------------- TITLE: [Observation on blood biochemical indices after gossypol -------------------------------------------------------------------------- treatment in gynecological cases] -------------------------------------------------------------------------- AUTHOR: Wang YF SOURCE: Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao 1988 Jun;10(3):215-8 NLM CIT. ID: 89028919 MAIN MESH Endometriosis/BLOOD/*DRUG THERAPY SUBJECTS: Gossypol/*THERAPEUTIC USE Leiomyoma/BLOOD/*DRUG THERAPY Uterine Neoplasms/BLOOD/*DRUG THERAPY ADDITIONAL Adult MESH SUBJECTS: Cholesterol/BLOOD English Abstract Female Human Lipoproteins, HDL/BLOOD Middle Age PUBLICATION JOURNAL ARTICLE TYPES: LANGUAGE: Chi REGISTRY 0 (Lipoproteins, HDL) NUMBERS: 303-45-7 (Gossypol) 57-88-5 (Cholesterol) -------------------------------------------------------------------------- TITLE: [Late effect of gossypol treatment in gynecological -------------------------------------------------------------------------- diseases--a clinical study of 72 cases] -------------------------------------------------------------------------- AUTHOR: Wang YF SOURCE: Chung Hsi I Chieh Ho Tsa Chih 1985 Apr;5(4):205-7, 194 NLM CIT. ID: 85201991 MAIN MESH Endometriosis/*DRUG THERAPY SUBJECTS: Gossypol/*THERAPEUTIC USE Leiomyoma/*DRUG THERAPY *Medicine, Chinese Traditional *Medicine, Oriental Traditional Uterine Neoplasms/*DRUG THERAPY ADDITIONAL Adult MESH SUBJECTS: English Abstract Female Follow-Up Studies Human Middle Age PUBLICATION JOURNAL ARTICLE TYPES: LANGUAGE: Chi REGISTRY 303-45-7 (Gossypol) NUMBERS: -------------------------------------------------------------------------- TITLE: Gossypol in the treatment of endometriosis and uterine -------------------------------------------------------------------------- myoma. -------------------------------------------------------------------------- AUTHOR: Han ML; Wang YF; Tang MY; Ge QS; Zhou LF; Zhu PD; Sun YT SOURCE: Contrib Gynecol Obstet 1987;16:268-70 NLM CIT. ID: 88081572 AUTHOR Department of Obstetrics and Gynecology, Peking Union AFFILIATION: Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. MAIN MESH Endometriosis/*DRUG THERAPY SUBJECTS: Gossypol/ADVERSE EFFECTS/*THERAPEUTIC USE Leiomyoma/*DRUG THERAPY Uterine Neoplasms/*DRUG THERAPY ADDITIONAL Adult MESH SUBJECTS: Female Follow-Up Studies FSH/BLOOD Human LH/BLOOD Middle Age Ovary/PHYSIOPATHOLOGY PUBLICATION JOURNAL ARTICLE TYPES: LANGUAGE: Eng REGISTRY 303-45-7 (Gossypol) NUMBERS: 9002-67-9 (LH) 9002-68-0 (FSH) -------------------------------------------------------------------------- TITLE: [Clinical and experimental study of gossypol in the -------------------------------------------------------------------------- treatment of dysfunctional menorrhagia, endometriosis -------------------------------------------------------------------------- and fibromyoma of the uterus] AUTHOR: Ye XQ SOURCE: Chung Hsi I Chieh Ho Tsa Chih 1988 Apr;8(4):216-7, 197 NLM CIT. ID: 89051922 MAIN MESH Endometriosis/*DRUG THERAPY SUBJECTS: Gossypol/*THERAPEUTIC USE Leiomyoma/*DRUG THERAPY Menorrhagia/*DRUG THERAPY Uterine Neoplasms/*DRUG THERAPY ADDITIONAL Adult MESH SUBJECTS: Aged Animal English Abstract Female Human Middle Age Rats PUBLICATION JOURNAL ARTICLE TYPES: LANGUAGE: Chi REGISTRY 303-45-7 (Gossypol) NUMBERS: -------------------------------------------------------------------------- Cumulative cost of this session is $2.10 -------------------------------------------------------------------------- --------------------------------------------------------------------------- -------------------------------------------------------------------------- [Help] [infosearch] [backfiles] [Log off IGM] [Return to Results] [Return to Search] National Library of Medicine: IGM Full Record Screen [Help] [infosearch] [backfiles] [Log off IGM] [Next Record] [Return to Results] [Return to Search] [Previous Record] --------------------------------------------------------------------------- Citation 1 of 1 from 1990-92 --------------------------------------------------------------------------- --------------------------------------------------------------------------- --------------------------------------------------------------------------- TITLE: [Effects of gossypol and GnRHa on the prostaglandins contents of endometriotic cell and in situ] AUTHOR: Huang HF; Wang M SOURCE: Chung Hsi I Chieh Ho Tsa Chih 1991 Sep;11(9):527-9, 515-6 NLM CIT. ID: 92127657 AUTHOR Dept. of Obstetrics and Gynecology, Zhejiang Medical AFFILIATION: University, Hangzhou. ABSTRACT: In order to study a direct effect of some traditional and western medicine on the prostaglandins (PGs) of endometriosis, endometriotic cell and endometrial cell in situ were cultured in vitro. 6-keto-PGF1 alpha and thromboxane (TXB2) were measured in the above cells using the RIA from the superfusates. These PGs changes after gossypol acetate, progesterone, danazol and gonadotrophin releasing hormone agonist (GnRHa) treatment were studied. High PGs levels were observed in endometriotic cell, and higher in endometrial cell in situ of patients than in endometrial cell of healthy persons (P less than 0.01). After treatment with drug (but not GnRHa), the prostacyclin (PGI2) and TXB2 content were reduced in endometriotic cell, and the TXB2 contents were reduced in endometrial cell in situ (P less than 0.01). These results indicate that endometriotic cell and endometrial cell in situ can produce more PGI2 and TXB2--at least in vitro, which perhaps may provide an explanation for the puzzling clinical phenomenon of endometriosis. Gossypol acetate, progesterone and danazol inhibit PGI2 and TXB2 content in endometrial cell of patients with endometriosis. It is pertinent to ask whether these drugs can be used to improve endometriosis-associated infertility or dysmenorrhea as well. MAIN MESH Endometriosis/*PATHOLOGY SUBJECTS: Gonadorelin/*PHARMACOLOGY Gossypol/*PHARMACOLOGY Pelvic Neoplasms/*PATHOLOGY 6-Ketoprostaglandin F1 alpha/*METABOLISM ADDITIONAL Adult MESH SUBJECTS: Endometrium/METABOLISM English Abstract Female Human Thromboxane B2/METABOLISM PUBLICATION JOURNAL ARTICLE TYPES: LANGUAGE: Chi REGISTRY 303-45-7 (Gossypol) NUMBERS: 33515-09-2 (Gonadorelin) 54397-85-2 (Thromboxane B2) 58962-34-8 (6-Ketoprostaglandin F1 alpha) -------------------------------------------------------------------------- --=====================_830585846==_ -------------------------------------------------------------------------- Content-Type: text/plain; charset="us-ascii" -------------------------------------------------------------------------- Mark Perloe, MD Atlanta Reproductive Health Centre, 285 Boulevard, NE, Suite 320, Atlanta, GA 30312 voice 404-265-3662 WWW Homepage: http://www.ivf.com I had a life once, now I have a computer Next message: Peter V. Weston, M.D.: "Re: need help with weird case." Previous message: mark decker: "clomid and single shot pergonal for first line obgyn's" Maybe in reply to: Mark Perloe: "gossypol for endometriosis in India"

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