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Re: Acyclovir and HERPES in pregFrom: Terrence.Jones@ncal.kaiperm.orgWed Apr 10 20:04:16 1996
Bert, as usual your investigation appears thorough and comprehensive. For the residents patient enuf to stick with us despite citing ref's from 1995 and before: remember to file away in your hippocampus Beh:cet's disease as a rare cause of recurrent HSV-negative mucocutaneous apthous ulcers.These are pre- dominantly oral, (at least initially), leukocytoclastic vasculitic ulcerations but can also manifest with ocular - neurologic - arthritic - & pulmonary sxs. The extra-mucocutaneous pathology tends to be pop-related, with the least often occurring symptoms occurring in pts from India (tends to be restricted to mucocutaneous in these pts). Tho familial patterns are identified (10%), the majority of pts lack any family hx (90%). Since we're swimming in AT III, proteins C/S, and Leiden V the past few months (not complaining :) ) it might be a good time to point out the assoc with this syndrome and defects in fibrinolysis which can lead to rather severe thromboembolic phenomena. Was wondering if anyone's given much thought to the mechanism of amino- pterin embryopathy. Would the spectrum of cranio-facial defects, along with those in the extremities, demonstrate a pattern of folate-depletion-mediated teratogenesis; or would a defect in cytokine activity, secondary to its anti- inflammatory action, be causing alteration in collagen-matrix-epithelial maturation? Just interested in any focused speculation... Terry.
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