Acyclovir and HERPES in pregnancy

From: Bert Gold (bgold@itsa.ucsf.EDU)
Wed Apr 10 16:57:03 1996


Doctors,

Please consult your libraries:

1) Pregnancy outcomes following systematic acyclovir exposure June 1, 1984- June 30, 1993; in Morbidity and Mortality Weekly Report, 42 (41): 806-809, October 22, 1993.

2) Andrews, EB; Yankaskas, BC; Cordero, JF, Schoeffler,K and Haupp, S. (1992) Acyclovir in pregnancy registry: Six years experience: The acyclovir in pregnancy registry advisory committee. Obstetrics and Gynecology 79 (1): 7-13.

3) Haddad, J, Layer, B.; Astruc, D.; Messer, J. and Lokiec, F. (1993) Oral acyclovir and recurrent genital herpes during late pregnancy. Obstetrics and Gynecology 82 (1) 102-4.

Anecdotally, I would confess to members of this list that for the longest time I thought I had Herpes Simplex, getting genital lesions under stress, however, after a thorough work-up looking at every possible antibody by Roche, whatever I have, it ain't herpes. That is perhaps why it never appears to respond to acyclovir... (Sometimes topical cortisone analogs help, but not consistently, and yes, I know that these would be contraindicated during pregnancy, I'm just trying to give you something to think about as you advise your patients.)

--
 Bert Gold, Ph.D.                         "If only we stay with that principle
 University of California, San Francisco   which counsels us always to hold
 School of Medicine                        to the difficult, then that which
 Department of Pediatrics                  now seems to us most foreign, will
 Program in Medical Genetics               become what we most trust and
 (415) 476-2850                            find most faithful." - R.M. Rilke




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