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Risk for Rh sensitizationFrom: Kenneth J. Moise (kmoise@bcm.tmc.edu)Sat Dec 30 21:24:02 1995
Dr. Kahaled Homouda asked if a patient undergoing spontaneous abortion at 6 weeks EGA is at risk for Rh sensitization. I would agree with Dave Nagey that the chances are unlikely but Rhesus immune globulin is probably indicated. I would not however agree that the patient is out of the woods until a titer is determined in her next pregnancy. She may belong to that group of "hyperresponders" that become sensitized with as little as 0.1 cc of RBC's. Bowman calls these individuals "sensibilized". In these cases a titer may not detect low grade sensitization but B lymphocyte memory cells are present. A titer would then become positive in a subsequent gestation when the patient is once again exposed to the antigen. Ken Moise Maternal-Fetal Medicine Baylor College of Medicine
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