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NO2 in laborFrom: Joshua Copel (Joshua.Copel@QuickMail.Yale.edu)Thu Dec 28 06:43:09 1995
>Subject: Time: 8:24 AM >OFFICE MEMO NO2 in labor >Date: 12/28/95 Jason Gardosi asked about use of nitrous oxide for laboring patients in the US. While I love nitrous at the dentist's for fillings, we don't use it here at Yale in laboring women because of the risk of aspiration pneumonitis with inhalational anesthesia (Mendelson Am J Obstet Gynecol 1946;52:191, that is not a typo, 1946 was publication date) . It would be interesting to know if the UK experience with this syndrome has been reported. Williams Obstetrics 19th edition associates aspiration more with failed intubation. My old edition of Shnider (2nd ed, 1987) Anesthesia for Obstetrics associated aspiration with inhalational agents in general, and also points out that there can be a significant fall in uterine blood flow in pregnant ewes experimentally given inhalational nitrous oxide. Josh Copel Yale Ob-Gyn, MFM Joshua.Copel@Yale.edu
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