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Adverse Effects: Estrogen/ProgestinsFrom: Hellriegel, Jr. John (JHellrie@ubmedd.buffalo.edu)Sat Dec 9 16:18:27 1995
Questions: Is Depo Provera or are progestins associated with an increased incidence of deep vein thrombosis or thrombosis of any organ system? Is Premarin associated with an increased incidence of thrombocytopenia? I have been using Depo Provera and Provera to treat postmenopausal symptoms in patients who have had breast cancer. Recently I was advised that I was placing these patients at increased risk for thrombosis due to the progestins. Except for three references in the Japanese literature (I do not understand Japanese), I have not been unable to find papers which demonstrate a link between progesterone, or Provera and thrombosis. I have a patient who is taking Premarin, 0.625 qd and is mildly thrombocytopenic. Her internist has told that the thrombocytopenia is caused by the Premarin and that she should stop it immediately. I am unable to find papers which demonstrate a link between thrombocytopenia and ERT. Your comments and references to these topics will be appreciated. John Hellriegel jhellrie@ubmedd.buffalo.edu
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