Corticosteroids and hyperemesis

From: R J Connell (rowan@pavilion.co.uk)
Sat Dec 9 13:26:40 1995


At last the protocol from Queen Charlotte's about the above. This is a multicentre RCT (double blind). It will go on for two years.

Inclusions: Onset of nausea <12/40 Iweek of IV fluids for first presenters or 24 hours for 2nd+ presenters. Have had one antiemetic ketonuric no uti normal blood glucose Vomitting >2x per day

Methods one week of oral prednisolone 20mg BD (12 hourly) if vomitting @ 72hours then IV(eg 100mg hydrocortisone or equivalent)

Pilot study showed a 100% reduction of vomitting after one week.

I have used this once this week I will agree with Pete Bridgwood it is quite a remarkable change!!

Details from Catherine Nelson-Piercy via cfc@rpms.ac.uk or Andy Shennan at ashennan@rpms.ac.uk

Hope this is satisfactory.

Best of luck-if you try it you WILL be amased!!!!

Rowan Rowan Connell London and Brighton

(I say no to Bordeaux. Chablis tastes like pee;

ad infinitum...

Good to see "they" have decided to stop earlier.)

rowan@pavilion.co.uk tel 0402-131525





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