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Re: Metformin versus Insulin for the Treatment of Gestational Diabetes From: Efrain Ramirez (eramirezt@coqui.net) Sun May 11 12:50:18 2008 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Efrain Ramirez: "Re: vbac on demand" Previous message: Garry E. Siegel, M.D.: "Re: vbac on demand" In reply to: Marie Harkins: "Re: Metformin versus Insulin for the Treatment of Gestational Diabetes" Bee using glyburide for approx. 2 years - no regrets....yet Ef At Sun, 11 May 2008, Marie Harkins wrote: > >I just returned from a conference on GDM and obesity where Donald >Coustan was one of the main speakers. He discussed this paper and >the use of Metformin for GDM treatment. He was reluctant to advocate >for use of Metformin for GDM and sited a study from Vankey et.al. >(Fertil Steril 83:1575,2005). This study had a small number of women >(n) taking Metformin throughout pregnancy and measured maternal >serum and cord artery and vein levels simultaneously at birth. All >cord bloods contained Metformin at higher levels than maternal serum. > >As mentioned in the article below, Metformin is a small molecule that >crosses the placenta. Dr Coustan felt that fetal effects of >Metformin have not been well studied and and that more trials or >animal studies would be helpful. On the other hand, he presented >good evidence that Metformin does improve early pregnancy loss rate >in women with PCOS, even if it is discontinued at the time of >diagnosis of pregnancy. > >-- >Marie Harkins, CNM >Ithaca, NY > -- "I can accept failure, but I can't accept not trying." - Michael Jordan Next message: Efrain Ramirez: "Re: vbac on demand" Previous message: Garry E. Siegel, M.D.: "Re: vbac on demand" In reply to: Marie Harkins: "Re: Metformin versus Insulin for the Treatment of Gestational Diabetes"

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