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Re: HPV vaccine and resistance From: Larry Glazerman (l.glazerman@rcn.com) Tue Oct 30 04:54:33 2007 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Douglas Krell: "Re: Gyn: Positive margins on a LEEP" Previous message: Larry Glazerman: "Re: Gyn: Positive margins on a LEEP" In reply to: Richard Chudacoff: "HPV vaccine and resistance" Next in thread: Richard Chudacoff: "Re: HPV vaccine and resistance" Reply: Richard Chudacoff: "Re: HPV vaccine and resistance" Rick: I'm an investigator for Gardasil (their current study in the 26-45 year old female population). At our most recent investigator's meeting, this issue came up. They gave several very elegant immunological reasons why this is very unlikely to happen, which make sense to me. I can't begin to explain the immunology, but one of the issues was that, unlike most bacteria, HPV subtypes are synergistic, rather than competitive. Apparently there's good data (don't ask how they got it) that this virus, again, unlike most bacteria, hasn't had significant mutation in thousands of years. Larry -- Larry R. Glazerman, MD, FACOG St. Luke's Center for Advanced Gynecologic Care 250 Cetronia Road Suite 305 Allentown PA 18104 484-223-3279 484-223-2830 FAX glazerl@slhn.org On Oct 29, 2007, at 6:54 PM, Richard Chudacoff wrote: > I think most of you are aware of the recent discovery of a virulent > and resistant strain of Strep pneumonia in upstate New York. It > appears this is a result of a vaccination program started about 8 > years ago to prevent ear infections in neonates and kids. Now, there > is this resistant strain, and only antibiotics withheld from > pediatric patients is the past seem to work. I still believe that > the MRSA endemic is related to the ubiquitous use of antibacterial > soaps. My question is this: why won’t the same thing happen with > HPV? Right now HPV is a little more than a nuisance in the regularly > screened population. What happens when it becomes more aggressive > due to the selecting out of relatively easy to treat strains? I am > feeling reluctant to giving this vaccine although now it is out > there perhaps the resistance is inevitable. > > Just my opinion, but I could be wrong…..then again, I could be right > > Richard Chudacoff, MD, FACOG > Las Vegas International Center for Advanced Gynecologic Care > (Specializing in minimally and non-invasive surgery) > 2481 Professional Court > Las Vegas, NV 89128 > TEL: 702-485-8893 > FAX: 702-974-0945 > > http://www.lasvegasgyncenter.com > http://www.exablateoflasvegas.com > Next message: Douglas Krell: "Re: Gyn: Positive margins on a LEEP" Previous message: Larry Glazerman: "Re: Gyn: Positive margins on a LEEP" In reply to: Richard Chudacoff: "HPV vaccine and resistance" Next in thread: Richard Chudacoff: "Re: HPV vaccine and resistance" Reply: Richard Chudacoff: "Re: HPV vaccine and resistance"

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