Re: Depo-Provera

From: Raymond Stephen (stephen.raymond@dhhs.tas.gov.au)
Tue Jun 12 21:12:56 2007


Of course she will, but the issue here is not so much with getting a withdrawal bleed per se, but in kick starting the pituitary ovarian axis, by inducing the negative feedback mechanism of oestrogen on FSH. One two week course of oestrogen in my experience is enough to get the cycles restarted after the pituitary ovarian axis has been shut down by Depo Provera. If she doesn't want her fertility back then of course the pill is going to have a place, but I was assuming (perhaps wrongly) that she had stopped the Depo in order to return to fertile cycles.

Steve

-----Original Message----- From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of Andrew Folley Sent: Wednesday, 13 June 2007 3:36 AM To: Multiple recipients of list OB-GYN-L Subject: Re: Depo-Provera

Disagree. Put an 80 year old woman on BCPs and she will start having periods. See Speroff.

>From: Rafael Haciski <haciski@earthlink.net>
>Reply-To: ob-gyn-l@obgyn.net
>To: Multiple recipients of list OB-GYN-L <ob-gyn-l@dns.obgyn.net>
>Subject: Re: Depo-Provera
>Date: Mon, 11 Jun 2007 22:25:35 -0500
>
>I agree with the OCP vs HRT, as she technically is in the range of HRT
tx >at present with her estrogen level.
>I do not think that menses is the issue, and if she is amenorrheic it
will >be OK (with me and the pt) but I am more concerned with the low
estrogen >levels and the effects on bone, and possible sporadic ovulation
leading to >an unintended pregnancy. Hence I would be perfectly OK with OCP
treatment >for the time being.
>
>Rafael Haciski MD FACOG
>Naples, FL.
>
>On Jun 11, 2007, at 6:59 PM, Raymond Stephen wrote:
>
>>Putting her on the OCP is not the best idea. It will probably
produce a >>withdrawal bleed, but as her problem is endometrial atrophy due to
long >>term progestogen exposure, what she needs is oestrogen. All OCPs
produce >>endometrial quiescence (atrophy) so any pill you give her will, in
>>theory, add to the problem unless there is sufficient oestrogen in
what >>she takes to give her some endometrial proliferation. Hence she will
get >>a better result from oestrogen alone, and that is why she should take

>>Premarin (or any other oestrogen you prefer). Andrew's last
statement >>"Estrogen supplement with pill or HRT would be adequate" is an
oxymoron >>as the OCP is more progestagenic than oestrogenic.
>>
>>Steve

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