Re: Reglan and breast milk

From: Yankowitz, Jerome (jerome-yankowitz@uiowa.edu)
Wed Jun 6 16:10:38 2007


consider doing a google for fda and domperidone. Several reports of cardiac arrest and irregular heart beats. FDA specifically warns against use and importing. Evidence for any significant effect of Reglan is weak. See paper in premies by Wendy Hansen when she was here at Iowa. Not definitive but some food for thought.

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From: ob-gyn-l@obgyn.net on behalf of Henry Gregor

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Sent: Wed 6/6/2007 3:41 PM
To: Multiple recipients of list OB-GYN-L
Subject: Re: Reglan and breast milk

Thanks Anna. I should have thought immediately of Dr. Hale...was looking at from the lactation milk production physiology view and not thinking of it from the use of meds in pregnant and lactating women point of view....the list proves its value once again, hehe.

Hank

"Meenan, Anna" <annam@uic.edu> wrote:

Just attended a lecture by Dr. Thomas Hale (author of Medications and Mothers Milk) last night. He recommends 10-15 mg TID and should see a response in 24-48 hours. He recommends checking a prolactin level, as if it is over 200, the Reglan will not work. I would draw prolactin level, start metoclopramide at 10TID, increase to 15 TID if no response in 2 days. If your prolactin comes back at over 200 ng'ML, and the med isn't helping, D/C it.

Be careful with metoclopramide. As many as 50% of moms who take it for more than 4 weeks will get depressed. An alternative is Domperidone, 20 mg tid, which is not available in the US, but can be made in a good compounding pharmacy or obtained with a scrip sent to a Canadian pharmacy. All the benefits without the side effects.

Also, if you do use metoclopramide. taper it by 10 mg q week. Don't stop abruptly.

Anna Meenan, MD

In the past I've prescribed reglan to help improve milk flow...have done that only rarely and so long ago, I can't remember what dosage/interval I used...would also wonder if others have used this successfully? Patient has tried all the usual measures re increasing production. Thanks for any input.

Hank

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