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Re: Methotrexate From: art fougner, md (evsono@pipeline.com) Sun Apr 29 20:54:45 2007 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Dr Eberhard Lisse: "Re: Abortion? ... here we go again! Sheesh! -->ConLaw now!" Previous message: R. Daniel Braun: "Re: Methotrexate" In reply to: R. Daniel Braun: "Re: Methotrexate" Next in thread: R. Daniel Braun: "Re: Methotrexate" Reply: R. Daniel Braun: "Re: Methotrexate" Am J Obstet Gynecol. 2002 Jun;186(6):1192-5. Oral methotrexate for treatment of ectopic pregnancy. Lipscomb GH, Meyer NL, Flynn DE, Peterson M, Ling FW. Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, USA. OBJECTIVE: The purpose of this study was to evaluate oral methotrexate tablets in the treatment of ectopic pregnancy. STUDY DESIGN: Patients with a diagnosis of ectopic pregnancy were offered oral methotrexate tablets rather that intramuscular injection. Oral methotrexate was given in 2 divided doses 2 hours apart at a dose of 60 mg/m(2) with standard 2.5 mg methotrexate tablets. Patients were followed up with the use of the same protocol that was used typically for intramuscular methotrexate. RESULTS: Nineteen of 22 patients (86%) were successfully treated. There was no statistical difference between patients who were treated successfully or unsuccessfully, with respect to initial human chorionic gonadotropin titers (P =.55), ectopic size (P =.77), or methotrexate dose (P =.18). Nineteen of 22 patients (86%) had increased pain during treatment. Outside of pain, gastrointestinal side effects were the most common. Thirty-two percent of patients required more than one treatment cycle. CONCLUSION: Oral methotrexate can be used to treat ectopic pregnancy successfully, but there are few advantages to recommend its use over intramuscular methotrexate. Art At Sun, 29 Apr 2007, R. Daniel Braun wrote: > >Steve, >Give us a reference ofr that. OR put all your data together and publish it. >Dan > >On 4/29/07, Raymond Stephen <stephen.raymond@dhhs.tas.gov.au> wrote: >> >> Yes I have used oral exclusively in the last decade. The dose is the >> same, but be aware that it is available in small dose tablets (I think 2 or >> 2.5mg), so ensure that he stocks the larger dose tablets otherwise your >> patients have to swallow 20 tablets at a time! >> >> Steve Raymond >> >> ------------------------------ >> >> ------------------------------ >> ------------------------------ >> ------------------------------ >> *From:* ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] *On Behalf Of *Elrod, >> ------------------------------ >> Darryl G Maj 48 MDOS/SGOBO >> ------------------------------ >> *Sent:* Friday, 27 April 2007 6:47 PM >> ------------------------------ >> *To:* Multiple recipients of list OB-GYN-L >> *Subject:* Methotrexate >> >> Does anyone have any experience with ORAL methotrexate for treatment of >> ectopic pregnancy? Our pharmacist is looking to try and get away from >> having to stock IM methotrexate. >> >> Thanks, >> >> Glen >> >> CONFIDENTIALITY NOTICE AND DISCLAIMER >> >> The information in this transmission may be confidential and/or protected >> by legal professional privilege, and is intended only for the person or >> persons to whom it is addressed. If you are not such a person, you are >> warned that any disclosure, copying or dissemination of the information is >> unauthorised. If you have received the transmission in error, please >> immediately contact this office by telephone, fax or email, to inform us of >> the error and to enable arrangements to be made for the destruction of the >> transmission, or its return at our cost. No liability is accepted for any >> unauthorised use of the information contained in this transmission. If the >> transmission contains advice, the advice is based on instructions in >> relation to, and is provided to the addressee in connection with, the matter >> mentioned above. Responsibility is not accepted for reliance upon it by any >> other person or for any other purpose. >> >-- >R. Daniel Braun, MD FACOG(L) CMT >Professor Emeritus >Dept. of Obstetrics and Gynecology >Indiana U. School of Medicine > >R. Daniel Braun > > "The way to health is an aromatic bath and scented massage everyday". > Hippocrates > -- art fougner, md "May The Wings of Liberty Never Lose a Feather." - Jack Burton Next message: Dr Eberhard Lisse: "Re: Abortion? ... here we go again! Sheesh! -->ConLaw now!" Previous message: R. Daniel Braun: "Re: Methotrexate" In reply to: R. Daniel Braun: "Re: Methotrexate" Next in thread: R. Daniel Braun: "Re: Methotrexate" Reply: R. Daniel Braun: "Re: Methotrexate"

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