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Re: HRT and cervical cancerFrom: =?utf-8?q?Dr. Bülent Potur?= (bpotur@yahoo.com)Wed Apr 25 14:00:30 2007
After the marketing of gardasil it seems it has been proven that the cx ca is a std or more politely is a sexually shared disease, meeting Koch's postulates. I think from now on we may discuss the way HRT may modify immune response and may affect the course of the disease. Progestagens are known to decrease immunity so I think we should beware. of it. Bulent Potur MD Obgyn Rafael Haciski <haciski@earthlink.net> wrote: But John, HRT levels are lower than OCP levels Rafael Haciski MD FACOG Palmetto, FL. On Apr 25, 2007, at 12:18 PM, Dr. John Provatopoulos B.Sc. M.D.C.M. F.R.S.C. wrote: At Wed, 25 Apr 2007, Elrod, Darryl G Maj 48 MDOS/SGOBO wrote: John, That is OCP use. What about HRT use? It doesn't say anything about its use and should we assume that OCP use and HRT use have the same risk? Glen -----Original Message----- From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of Dr. John Provatopoulos B.Sc. M.D.C.M. F.R.S.C. Sent: Wednesday, April 25, 2007 3:13 PM To: Multiple recipients of list OB-GYN-L Subject: Re: HRT and cervical cancer At Wed, 25 Apr 2007, Elrod, Darryl G Maj 48 MDOS/SGOBO wrote: I just had a question from the internist that several patients have asked her about a link between HRT and cervical cancer. I haven't seen or read anything about this link and frankly, it just doesn't make any sense. Has there been a report in Women's Day or something recent? Glen Good point Glen, I agree we shouldn't assume same effects, my point is we don't see a second wave of cervical Ca. despite the decades of HRT use, there is a small blip but that's more related to women stoping routine screening to early in thier lives. If the premise is hyperestrogen cause cervical ca, then no OBCP >OPCP>HRT. People are surprised when I tell them being on the OBCP is relatively hypoestrogenic relative to natural cycles. The american cancer society has a very nice site, a few studies have shown a link with OBCP use, but most long term users of OBCP also have other risk factors so its probably not clear cut. We know it takes at least 3-5 years to develop invasive cervical cancer, most women start HRT > 45 years,so if there was a strong association we would a seen a large second wave of cervical cancer in the > 55 y.o. crowd, so I don't think we will ever see a strong link IMHO. http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_f actors_for_cervical_cancer_8.asp
--
Take care, John
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