Re: Hydroxyprogesterone
From: R. Daniel Braun (rd.braun@gmail.com)
Fri Oct 27 08:16:16 2006
That is why you have a control group that is similar to the treatment group..
For when all your patients are diferent than the average around the
country.If this were a fancy new machine that everyone could make lots of
money by using it, there would be no question.
Dan
On 10/26/06, Andrew Folley <agfolley@hotmail.com> wrote:
>
> What is the problem here, it is an effective drug with little if
> >anything in
> >the way of side effects and no one wants to use it.
> >
> >Dan
>
> The problem may be that the current sutdies are not really supporting the
> benefit of use of 17 oh progesterone. Meis studies showed that when given
> 17-oh- P the risk of premature labor in the high risk women with a hx of
> previous premature labor was about 36%. It was significantly less than
> the
> placebo group getting IM castor oil shots. But it is about the same risk
> tha we findll for women who do not get anything. ie 30% chance of having
> a
> recurrence of premature delivery. what are we to conclude? andrew
>
> Results Base-line characteristics of the 310 women in the progesterone
> group
> and the 153 women in the placebo group were similar. Treatment with 17P
> significantly reduced the risk of delivery at less than 37 weeks of
> gestation (incidence, 36.3 percent in the progesterone group vs. 54.9
> percent in the placebo group; relative risk, 0.66 [95 percent confidence
> interval, 0.54 to 0.81]),
>
> >From: "R. Daniel Braun" <rd.braun@gmail.com>
> >Reply-To: ob-gyn-l@obgyn.net
> >To: Multiple recipients of list OB-GYN-L <ob-gyn-l@dns.obgyn.net>
> >Subject: Re: Hydroxyprogesterone
> >Date: Wed, 25 Oct 2006 20:08:24 -0500
> >
> >In the studies by Johnson from Hopkins in the 70's, it cut it by 35%
> under
> >the placebo group. He took anyone who was at high risk for preterm del;
> >twins trips prior ppreterm del fibroids etc and randomized them. It did
> >about the same, in the lge MFM protocol.
> >In the late 70's it wasn't used because we had these great exciting
> Beta-2
> >sympathomimetics to play with and they were a lot more fun than to give a
> >weekly shot.
> >>
> >
> >On 10/25/06, Andrew Folley <agfolley@hotmail.com> wrote:
> >>
> >>If the 17 0h Progesterone caproate is the panacea of premature labor
> then
> >>why arent many of the drug companies manufacturning it???? If the
> >>literature supports it it should be a billion dollar business in light
> of
> >>all the premature birts we have 12% and their getting pregnant again and
> >>again.
> >>
> >>why is it only available for the most part out of a pharmacy in New
> >>Jersey?
> >>
> >>What does the literature show about 17 Oh progesterone???? what were the
> >>rates of PML in the 17oh arms verses the placebo arm? What is the risk
> of
> >>PML in the general population?
> >>
> >> >From: "AFuentes" <afuentes@mindspring.com>
> >> >Reply-To: ob-gyn-l@obgyn.net
> >> >To: Multiple recipients of list OB-GYN-L <ob-gyn-l@dns.obgyn.net>
> >> >Subject: RE: Hydroxyprogesterone
> >> >Date: Wed, 25 Oct 2006 15:47:01 -0500
> >> >
> >> >I agree...where are the studies that substantiate the use of theres
> two
> >> >types of progesterone.
> >> >
> >> >Matria provides a nurse and weekly 17P injections in the home if the
> >> >insurance covers it.
> >> >Also, Adeza has received tentative approval for 17P, called Gestiva
> from
> >> >the
> >> >FDA. Google "Adeza" and you will see the latest FDA status.
> >> >
> >> >A.Fuentes
> >> >Director
> >> >Maternal Fetal Center
> >> >Orlando,FL
> >> >
> >> > _____
> >> >
> >> >From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of R.
> >>Daniel
> >> >Braun
> >> >Sent: Wednesday, October 25, 2006 9:25 AM
> >> >To: Multiple recipients of list OB-GYN-L
> >> >Subject: Re: Hydroxyprogesterone
> >> >
> >> >And the location of the studies using "prometrium" and "prochieve" is:
> >> >??????
> >> >
> >> >Dan
> >> >
> >> >On 10/25/06, Andrew Folley <agfolley@hotmail.com> wrote:
> >> >
> >> >Glen
> >> >Wedgewood Pharmacy at 800-331-8272 is one source. It used to be about
> >>$125
> >> >for a 10cc vial providing 10 doses.
> >> >
> >> >For what it is worth, we have been using alternate delivery forms for
> >> >giving
> >> >the progesterone Specifically. we have been using prometrium at 200mg
> po
> >> >bid
> >> >at 20 weeks till term and some are
> >> >even using progesterone cream ie Prochieve 4% daily application. The
> >> >studies on these two sources are not yet in but many question the
> >>validity
> >> >of the 17 oh progesterone studies in terms of whether there is a true
> >> >reduction in premature deliverines. I consider this the art of
> >>medicine.
> >> >andrew
> >> >
> >> > >From: "Elrod, Darryl G Maj 48 MDOS/SGOBO"
> >> ><Darryl.elrod@LAKENHEATH.AF.MIL>
> >> > >Reply-To: ob-gyn-l@obgyn.net
> >> > >To: Multiple recipients of list OB-GYN-L <ob-gyn-l@dns.obgyn.net>
> >> > >Subject: Hydroxyprogesterone
> >> > >Date: Wed, 25 Oct 2006 05:24:06 -0500
> >> > >
> >> > >I know we have discussed the use of hydroxyprogesterone for the
> >> > >prevention of preterm labor before. My question now is regarding
> >> > >supplier of the medication. We are having a hard time getting the
> >>drug
> >> > >for our patients.
> >> > >
> >> > >If anyone has a manufacturer or a pharmacy they could recommend,
> could
> >> > >you please pass on that information.
> >> > >
> >> > >Thanks,
> >> > >
> >> > >Glen
> >> > >
> >> > >//SIGNED//
> >> > >
> >> > >D. Glen Elrod, Maj., USAF, MC
> >> > >
> >> > >Obstetrician/Gynecologist
> >> > >
> >> > >Chief of Obstetrics
> >> > >
> >> > >48 MDOS/SGOBO
> >> > >
> >> > >RAF Lakenheath, England
> >> > >
> >> > >Telephone DSN: 314-226-8130
> >> > >
> >> > > Comm: +44 (0) 1638 52 8130
> >> > >
> >> > >Notice of Confidentiality
> >> > >Under the Privacy Act of 1974, you must safeguard all information
> >> > >reflected on this e-mail and, if applicable, all attachments.
> >> > >Disclosure of information is IAW AFI 33-119, AFI 33-127, AFI 37-131,
> >>AFI
> >> > >37-132, AFI 33-219, and PL 93-579"
> >> > >This e-mail message including any attachments is for the sole use of
> >>the
> >> > >intended recipient(s) and may contain confidential and privileged
> >> > >information. Any unauthorized review, use, disclosure or
> distribution
> >>is
> >> > >prohibited. If you are not the intended recipient, please contact
> the
> >> > >sender by reply e-mail and destroy all copies of the original
> message.
> >> > >Any questions pertaining to disclosure should be directed to the
> >>privacy
> >> > >officer.
> >> > >
> >> >
> >> ><
> >>
> http://imagine-windowslive.com/search/kits/default.aspx?kit=improve&locale> >> >en-US&source=hmtagline> &locale=en-US&source=hmtagline
> >> >
> >> >--
> >> >R. Daniel Braun
> >> >
> >> > "The way to health is an aromatic bath and scented massage
> >> >everyday".
> >> > Hippocrates
> >>
> >
> >--
> >R. Daniel Braun
> >
> > "The way to health is an aromatic bath and scented massage
> >everyday".
> > Hippocrates
>
--
R. Daniel Braun
"The way to health is an aromatic bath and scented massage everyday"..
Hippocrates
