Re: Cytotec

From: Bernard Cristalli (bcrist@club-internet.fr)
Fri May 12 02:50:37 2006


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Cytotec induces contractions (Prostaglandin), therefore it's contraindicated in the early pregnancy. BC

GA12L@aol.com a écrit :

> I'm sorry, but I don't understand why Cytotec is used to induce
> labour. Pharmacia Limited who market Cytotec here clearly state that
>
> "Cytotec is contraindicated in pregnant women and in women planning a
> pregnancy as it increases uterine tone and contractions in pregnancy
> which may cause partial or complete expulsion of the products of
> conception. Use in pregnancy has been associated with birth defects."
>
> Cytotec is indicated for the healing of duodenal ulcer and gastric
> ulcer including those induced by nonsteroidal anti-inflammatory drugs
> (NSAID) in arthritic patients at risk, whilst continuing their NSAID
> therapy. In addition, Cytotec can be used for the prophylaxis of
> NSAID-induced ulcers. It says nothing about using it to induce labour
> in fact Pharmacia says that when used in pre-menopausal women they
> should ensure that they have adequate contraception. The Summary of
> Product Characteristics (SPC) clearly says in the section Undesirable
> effects
>
> "A number of side effects have been reported in clinical studies or in
> the literature following use of misoprostol for non-approved
> indications. These include abnormal uterine contractions, uterine
> haemorrhage, retained placenta, amniotic fluid embolism, incomplete
> abortion and premature birth."
>
> So using Cytoec for inducing labour is a) using it for a non-approved
> indication and b) it CAN cause AFE.
>
> So why is it used to induce labour? Sorry, I don't understand but I'm
> sure one of you will enlighten me!
>
> Gail
>





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